|
週次 |
日期 |
單元主題 |
|
第1週 |
9/17 |
•Introductory to Course : Chemistry and Structure - “We cannot accurately describe at the chemical level how a molecule functions unless we first know its structure” - James Watson [Chapter 1.4]
•Basics of Bioorganic Chemistry for Life; Bonds and Energetics of Biomolecules
|
|
第2週 |
9/24 |
Basics of Protein Structures I [Chapter 2]
- Amino Acids and the side chain chemistry - oxidation, hydroxylation, deamidation, carboxylation, acetylation, methylation
- Protein chemical modification, labeling and ligation
|
|
第3週 |
10/01 |
Basics of Protein Structures II [Chapter 2]
- Protein backbone and Secondary Structure
- Topologies, Motifs, Domains
|
|
第4週 |
10/08 |
Basics of Protein Structures III [Chapter 2]
- Folds, Stability and Dynamics
- Protein-Protein Interactions, Oligomeric Complex Assembly
|
|
第5週 |
10/15 |
Basics of Mass spectrometry based Proteomics
- Protein ID and Sequencing; mapping Protein Modifications and Interactions
|
|
第6週 |
10/22 |
Basics of Nucleic Acid Structure I [Chapter 3]
- Nucleotides & the Double Helix
|
|
第7週 |
10/29 |
Basics of Nucleic Acid Structure II [Chapter 3]
- Higher Structures and Nucleosomes
- Tertiary Structure of RNA
|
|
第8週 |
11/05 |
Basics of Lipids and Membrane Structure [Chapter 4] |
|
第9週 |
11/12 |
期中考 |
|
第10週 |
11/19 |
Structural View of DNA Replication and Recombination [Chapter 6]
- DNA Helicases, Polymerases, Telomerases
- DNA-repairing Glycosylases and RecA
|
|
第11週 |
11/26 |
Structural View of Transcription [Chapter 7]
- Promoters, Regulatory Elements, Histone Modifications, Chromatin
- Transcription Factors
|
|
第12週 |
12/03 |
Structural View of Translation [Chapter 8]
- tRNA synthetases and Ribosomes
- Initiation, Elongation, Translocation
|
|
第13週 |
12/10 |
Protein Folding and Degradation [Chapter 9]
- Molecular Chaperones and Protein Folding
- Serpins and Proteolytic Cleavages
- ERAD, Ubiquitin Pathway and Proteasomes
|
|
第14週 |
12/17 |
Protein Glycosylation I
- Monosaccharides and The Host Glycosylation Machinery
- Co-translational Modification in ER and Protein Folding QC cycle
|
|
第15週 |
12/24 |
Protein Glycosylation II
- Post-translational Modifications and Generation of Diversity in Golgi
- Terminal Glycosylation as Recognition Codes
- Considerations for Recombinant Glycoproteins productions
|
|
第16週 |
12/31 |
Membrane Proteins [Chapter 10]
- Membrane Protein Structures
- Protein Myristoylation and Prenylation and GPI-anchor
- Membrane Channels and Transporters
|
|
第17週 |
1/07 |
Phosphorylation and Signal Transduction [Chapter 11]
- Basics of Ser/Thr, Tyr and Histidine phosphorylation; O-GlcNAcylation
- Receptor Tyrosine Kinases and Phosphatases Pathways
|